这一顾虑固然有其道理。然而，锂中毒离我们究竟有多远，其临床危险性又有多大？一项6月14日发表于《Journal of Psychopharmacology》的回顾性队列研究中，研究者探讨了1997-2013年间瑞典1340名使用锂盐治疗的患者的锂中毒情况，其中给药24小时内血锂浓度超过治疗窗、达到中毒剂量定义为“急性”中毒，其他为“慢性”中毒；研究者记录了受试者血锂水平≥1.2mmol/L及≥1.5mmol/L的次数，以及锂中毒临床表现、躯体共病、是否需要透析、中毒至少一个月后的临床转归等。
文献索引：Ott M, et al. Lithium intoxication: Incidence, clinical course and renal function - a population-based retrospective cohort study. J Psychopharmacol. 2016 Jun 14. pii: 0269881116652577. [Epub ahead of print]
Lithium "is a toxic metal with no known function in the body....it interferes with nerve transmission in general, slowing down the responses to the brain." "Consistent with its toxic effects on the nervous system, lithium causes a tremor in 30-50 percent of patients. Tremors can be a warning sign of impending serious toxicity of the brain, especially if it occurs along with other danger signals, such as memory dysfunction, reduced concentration, slowed thinking, confusion, disorientation, difficulty walking, slurred speech, blurred vision, ringing in the ears, nausea, vomiting and headache. Muscle aches and twitches, weakness, lethargy and thirst are other common signs of lithium toxicity. In the late stages of lithium toxicity, the patient may become delirious and succumb to seizures and coma. EEG studies indicate an abnormal slowing of brain waves in a significant portion of patients routinely treated with lithium; the condition worsens with toxicity." (for complete information see Dr. Breggin's medical text Brain Disabling Treatments in Psychiatry Second Edition.)
楼主: 大财
发表于 2017-5-29 16:53:33
